Custom Peptides
Cayman Chemical PlecnatIdeacetate 10mg
A peptide agonist of the guanylate cyclase C receptor; stimulates cGMP production in T84 cells (EC50 = 170 nM); reduces increases in the number of neoplastic colon epithelial cells expressing Ki-67 induced by DSS in cancer-prone Apc+/Min-FCCC mice at 10 ppm in the diet; suppresses trinitrobenzenesulfonic acid-induced increases in abdominal contractions in a rat model of visceral hypersensitivity at 0.01 and 0.05 mg/kg
Cayman Chemical NItIdInchlorIde 10mg
An alkaloid; active against the F32 chloroquine-sensitive (IC50 = 0.52 µM) and FcB1 and FcM2 chloroquine-resistant strains of P. falciparum (IC50s = 0.52, 0.8, and 0.49 µM, respectively) and reduces parasitemia in a mouse model of P. vinckei infection (ED50 = 18.9 mg/kg per day); decreases LPS-induced increases in TNF-α, IL-1β, and IL-6 levels and p65 nuclear translocation in RAW 264.7 cells at 5 µM; decreases serum levels of IL-10, TNF-α, and IL-6 and reduces mortality in a mouse model of LPS-induced endotoxemia; inhibits proliferation of various cancer cells (IC50s = 2.65-370 ng/ml); induces apoptosis and decreases STAT3 phosphorylation in HSC3 and HSC4 oral cancer cells from 0.1-10 µM and reduces tumor growth in an HSC3 mouse xenograft model at 10 mg/kg per day for 24 days
Cayman Chemical 5-EAPBhydrochlorIde 10mg
An analytical reference standard categorized as a benzofuran; increases conditioned place preference for the 5-EAPB-paired chamber and reinforcement in a self-administration test in rats; has been found in seized samples suspected of containing NPS; associated with fatality; intended for research and forensic applications
Cayman Chemical N-ButylfluoresceIn 10mg
Ex/em = 467/512 nm, respectively; has been used in the synthesis of butyl FLIP, a fluorogenic substrate of PI-PLC
Cayman Chemical R1487hydrochlorIde 10mg
An inhibitor of p38α MAPK (IC50 = 10 nM); selective for p38α over p38β MAPK (Kds = 0.2 and 29 nM, respectively), as well as a panel of 306 additional kinases at 10 µM, but does inhibit 11 kinases by >85% at 10 µM; inhibits LPS-induced IL-1β production in isolated human whole blood (IC50 = 170 nM); inhibits LPS-induced production of TNF-α and IL-6 in rats (ED50s = 0.8 and 0.4 mg/kg); reduces yeast-induced hyperalgesia in rats (ED50 = 5.5 mg/kg)
Cayman Chemical PseudoprotodIoscIn 10mg
A steroidal saponin; cytotoxic to A375, L929, and HeLa cancer cells (IC50s = 5.73, 5.09, and 3.32 µM, respectively); increases ERα nuclear accumulation in 3T3-L1 preadipocytes cultured in differentiation medium; inhibits LPS-induced increases in NF-κB activity in reporter assays using isolated mouse peritoneal macrophages and HUVECs; reduces atherosclerotic plaque area and inhibits increases in serum total cholesterol and triglyceride levels in ovariectomized ApoE-/- mice fed a high-cholesterol diet at 1, 2.5, and 5 mg/kg
Cayman Chemical Gnkgo bloba L Blobalde 10mg
A sesquiterpene lactone which protects against cerebral edema, decreases cortical infarct volume, and reduces cerebral ischemic damage; at 10 μM, reduces the release of glycine and glutamate from hippocampal slices under ischemic conditions; increases the levels and activities of several cytochrome P450 isoforms in rat liver microsomes
Cayman Chemical FluorocleboprIde 10mg
A benzamide analog that is used in PET applications; binds dopamine receptors (Kis = 0.95, 5.7, 5.46, and 144 nM for D2(long), D3, and D4 receptors, respectively); selective for these receptors over D1, serotonin 5-HT2, and α2-adrenergic receptors (Kis = >10,000, 283, and 1,300 nM, respectively); a fluorine-18 moiety has been used to label this compound for use as a probe for studying D2/D3 receptor availability via PET in various monkey models
Cayman Chemical GardenosIde 10mg
An iridoid glycoside with anti-inflammatory and antinociceptive activities; decreases free fatty acid-induced accumulation of lipid droplets and increases in TNF-α, IL-6, and IL-1β levels in HepG2 cells at 10 and 20 µM; reduces increases in the expression of purinergic P2X3 and P2X7 receptors, as well as reverses decreases in mechanical withdrawal thresholds in a rat model of chronic constriction injury-induced neuropathic pain
Cayman Chemical GalactosylsphngosInd18 1 10mg
A bioactive sphingolipid; potentiates LPS-induced production of inflammatory cytokines, decreases the mitochondrial membrane potential, and induces cell death in mouse astrocytes; induces demyelination of mouse cerebellar slices at 0.1 and 1 µM; inhibits PDGF-induced translocation of PKC to the cell surface and induces apoptosis in MO3.13 oligodendrocytes; inhibits PPARα-mediated gene transcription in C6 glial cells at 10 and 15 µM; levels are increased in postmortem brain from patients with Krabbe disease
Cayman Chemical FondaparInuxsodIum salt 10mg
An inhibitor of Factor Xa (IC50s = 40, 45, and 36 nM for human, rabbit, and rat enzymes, respectively); binds to antithrombin III (Kds = 48, 132, 78, and 50 nM for human, rabbit, baboon, and rat, respectively); inhibits thrombin generation through the extrinsic and intrinsic routes (IC50s = 0.3 and 2.8 µM, respectively); dose-dependently inhibits thrombus formation in a rabbit model of venous thrombosis with complete inhibition of clot formation at a dose of 200 UG/kg
Cayman Chemical Suzetrgn 10mg
A Nav1.8 inhibitor (IC50 = 0.7 nM for the human channel); selective for Nav1.8 over a panel of eight additional voltage-gated sodium channels (IC50s = >10,000 nM for all)
Cayman Chemical CarbamazepIn 10 11epoxIde 10mg
An active metabolite of carbamazepine; has anticonvulsant activity against maximal electroshock-induced seizures in mice; has been found in wastewater effluent
Cayman Chemical 5fluoro PB22 6hdroxIsoqu 10mg
Differs from 5-fluoro PB-22 by having the quinoline group replaced with an isoquinoline group attached at its six position; intended for forensic and research purposes
Cayman Chemical EpIpregnolon 10mg
A neurosteroid and an active metabolite of pregnenolone; inhibits spontaneous contractions in myometrial strips isolated from at-term pregnant women (IC50 = 156 µM); decreases operant alcohol self-administration in rats at 10 and 20 mg/kg